The characteristic lumps are collections of immune cells clustered in pockets within the subcutaneous layer. The subcutaneous layer is the deepest, and provides support and structure for the overlying dermis and epidermis.Įrythema nodosum is an immunological response. The lumps tend to recur if the person doesn't have sufficient rest.Įrythema nodosum - immune cellsThe skin consists of three main layers, being the epidermis, the dermis and the subcutaneous layer.The purple lumps become brownish-yellow and flat over a few weeks.The lumps turn from bright cherry red to purple over a few days.Around half of all cases are associated with joint pains, particularly the knees.Up to 50 lumps may develop in the affected area.The lumps can be from 1 cm to 20 cm wide.Raised red, hard, hot and painful lumps appear on the skin.Other areas that may be affected include the ankles, calves, thighs, buttocks and arms.The skin on the shins is most commonly affected.Symptoms of erythema nodosumThe symptoms include: Even with treatment, the inflamed nodules can take around three to six weeks to resolve. The trigger remains unknown in many cases. The specific cause of erythema nodosum is unknown, but the condition can be triggered by certain drugs, diseases and infections. ![]() ![]() Children under the age of 15 years are very rarely affected. The condition is three times more common in women than men, and tends to develop somewhere between 20 and 45 years of age. Erythema nodosum appear as red tender lumps, most commonly on the shins or lower legs.
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